Table 1. Mutations Found in the ramR gene in Tigecycline Resistant K. pneumoniae Isolates.
| Strain | Sample | ESBL | tet | ramR |
|---|---|---|---|---|
| 1639 | 38 | CTX-M-15 | A | Stop codon |
| 11 | 14 | A | Stop codon | |
| 11 | 21 | Frameshift mutation | ||
| 11 | 30 | Stop codon | ||
| 11 | 33 | CTX-M-15 | ISKpn18 fragment insertion | |
| 11 | 34 | CTX-M-3 | ISKpn18 fragment insertion | |
| 11 | 59 | Stop codon | ||
| 15 | 17 | A | Alanine to Valine | |
| 36 | 45 | A | Stop codon | |
| 37 | 32 | A | Alanine to Valine | |
| 65 | 4 | Isoleucine to threonine | ||
| 252 | 56 | Aspartic acid to Histidine | ||
| 270 | 48 | Stop codon | ||
| 273 | 36 | CTX-M-15 | A | Stop codon |
| 273 | 58 | CTX-M-15 | C insertion; frameshift | |
| 307 | 44 | A | Tyrosine to Histidine | |
| 307 | 47 | A | Isoleucine to Leucine | |
| 307 | 54 | CTX-M-15 | A | Threonine to Isoleucine |
| 375 | 42 | Isoleucine to threonine | ||
| 564 | 20 | Lysine to Glutamine | ||
| 581 | 31 | A | Glycine to Glutamic acid, Aspartic acid to Histidine | |
| 789 | 11 | CTX-M-15 | Large fragment deletion | |
| 789 | 26 | CTX-M-15 | Plasmid fragment insertion | |
| 789 | 27 | Stop codon | ||
| 789 | 28 | CTX-M-15 | Stop codon | |
| 789 | 29 | CTX-M-15 | Stop codon | |
| 793 | 46 | C insertion; frameshift |
ESBL, extended-spectrum beta-lactamase.