Table 1.
Summary of Elicited Responses and Correlations With Number of Challenges to Infection
| Immunological Assay Performed | Peak |
Prechallenge |
||||
|---|---|---|---|---|---|---|
| Valuea | rb | P Valuec | Value | r | P Value | |
| SIVmac239 gp140-specific IgG in serum (μg/mL) | 241.5 (181, 327) | 0.32 | .04 | 37 (26, 37) | 0.32 | .03 |
| SIVmac239 gp140-specific IgG in rectal swabs (ng of specific IgG/μg IgG) | 11.2 (7.5, 18.23) | 0.17 | .30 | 1.6 (0.7, 2.9) | 0.42 | .006 |
| SIVmac239 gp140-specific IgG secreting ASCs (ASCs/10^6 PBMCs) | 116 (52.5, 223.5) | 0.53 | .01 | |||
| SIVmac239 gp140-specific IgA secreting ASCs (ASCs/106 PBMCs) | 45 (22.5, 82.0) | 0.63 | .02 | |||
| SIVmac251 gp140-specific IgA in serum (μg/mL) | 0.63 (0.38, 1.15) | 0.34 | .03 | |||
| SIVmac239 gp160-specific Avidity index | 49 (43.0, 53.7) | 0.01 | .9 | |||
| Neutralizing titers against challenge virus (SIVsmE660-ABL) | 3078 (1440, 4710) | 0.12 | .4 | 446 (168, 7.3) | 0.18 | .3 |
| ADCP score | 57 (51.7, 68.7) | 0.22 | .2 | |||
| ADCC activity (AUC values) | 2.06 (1.32, 2.57) | 0.24 | .13 | |||
| SIV-specific IFNγ+CD4+ T-cell response | 0.21 (0.11, 0.67) | 0.11 | .7 | 0.08 (0.05, 0.17) | 0.13 | .5 |
| SIV-specific IFNγ+CD8+ T-cell response | 0.35 (0.2, 1.2) | 0.01 | .9 | 0.04 (0.02, 0.15) | 0.05 | .8 |
Abbreviations: ADCC, antibody-dependent cellular cytotoxicity; ADCP, antibody-dependent cellular phagocytosis; ASCs, antibody-secreting cells; AUC, area under the curve; gp, glycoprotein; IFN, interferon; Ig, immunoglobulin; PBMCs, peripheral blood mononuclear cells; SIV, simian immunodeficiency virus; SIVmac239, SIV macaque 239.
a Median (25th, 75th percentiles).
b Spearman correlation coefficient.
c Two-tailed P value, unadjusted for Bonferroni correction.