Table 3. False-positive report probability values for associations between the nitric oxide synthase 3 polymorphisms and the preeclampsia risk.
Genotype | Crude OR (95% CI) | P-valuea | Statistical powerb | Prior probability |
||||
---|---|---|---|---|---|---|---|---|
0.25 | 0.1 | 0.01 | 0.001 | 0.0001 | ||||
G894T | ||||||||
Recessive genetic model | 1.46 (1.21, 1.77) | <0.001 | 0.710 | 0.003 | 0.009 | 0.089 | 0.496 | 0.908 |
High-quality score | 1.59 (1.27, 2.00) | <0.001 | 0.453 | 0.005 | 0.014 | 0.133 | 0.607 | 0.939 |
T-786C | ||||||||
Recessive genetic model | 1.30 (1.07, 1.58) | 0.008 | 0.590 | 0.004 | 0.011 | 0.105 | 0.542 | 0.922 |
Caucasian | 1.41 (1.11, 1.79) | 0.005 | 0.303 | 0.007 | 0.020 | 0.186 | 0.698 | 0.958 |
African | 2.44 (1.26, 4.71) | 0.008 | 0.008 | 0.204 | 0.435 | 0.894 | 0.988 | 0.999 |
High-quality score | 1.47 (1.14, 1.89) | 0.003 | 0.241 | 0.009 | 0.026 | 0.224 | 0.744 | 0.967 |
OR: odds ratio; CI: confidence interval;
aChi-square test was used to calculate the genotype and haplotype frequency distributions.
bStatistical power was calculated by using the number of observations in the subgroup and the OR and P values in this table.