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. Author manuscript; available in PMC: 2017 Mar 15.
Published in final edited form as: Circulation. 2016 Mar 15;133(11):1115–1124. doi: 10.1161/CIRCULATIONAHA.115.018622

Figure 1.

Figure 1

Effects of valsartan/sacubitril through inhibition of neprilysin (NEP) and blockade of the renin-angiotensin-aldosterone system. Red represents antagonism/inhibition. Ang I indicates angiotensin I; Ang II, angiotensin II; AT1R, angiotensin type 1 receptor; ARB, angiotensin receptor blocker; ACE, angiotensin-converting enzyme; APP, aminopeptidase P; ADM, adrenomedullin; NEPi, neprilysin inhibitor; ANP, atrial natriuretic peptide; BNP, brain natriuretic peptide; and CNP, C-type natriuretic peptide.