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Organ biodistribution of free 6BIO, the linear micelle BIO-A2-D8, and the branched micelle BIO-A2-K-D4 measured in percent of injected dose/gram of tissue. Of particular interest the drug accumulation was significantly higher in the fractured femur over the healthy femur in both of our targeted micelles (p<0.001). The accumulation in fractured femurs was also significantly higher in the targeted groups over the free drug (p<0.001).
