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. Author manuscript; available in PMC: 2016 Mar 21.
Published in final edited form as: Exp Neurol. 2014 Dec 2;264:135–149. doi: 10.1016/j.expneurol.2014.11.009

Figure 3. Greater delayed effects of KA in GFAP-TK+ mice compared to GFAP-TK−mice.

Figure 3

A. The experimental timeline is shown. Animals were treated with ethosuximide and 20 mg/kg KA. IIS were analyzed during the 4–21 hrs after KA as shown. Sample sizes are as follows: GFAP-TK−: n = 7; GFAP-TK+: n = 6.

B. Representative examples of IIS from a GFAP-TK− (1) and GFAP-TK+ (2) mouse. For 1–2, the trace to the right shows an IIS at higher temporal resolution. Qualitatively, IIS had similar morphologies. 3. There was a higher IIS frequency in GFAP-TK+ mice compared to GFAP-TK− mice at all the time points tested.

C. 1–2. Representative examples of records from a GFAP-TK− and a GFAP-TK+ mouse at similar delays (approximately 7.5 hrs) after KA.

3. The number of mice with delayed seizures was not significantly greater in GFAP-TK+ mice compared to TK− mice, but the mean number of seizures per mouse was greater in GFAP-TK+ mice.