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. Author manuscript; available in PMC: 2016 Mar 21.
Published in final edited form as: Exp Neurol. 2014 Dec 2;264:135–149. doi: 10.1016/j.expneurol.2014.11.009

Figure 4. Greater delayed effects of KA in X-irradiated mice compared to sham controls.

Figure 4

A. The experimental timeline is shown. Animals were treated with ethosuximide and 20 mg/kg KA. IIS were analyzed during the 4–21 hrs after KA. Sample sizes are as follows: GFAP-TK−: n = 8; GFAP-TK+: n = 7.

B. Representative examples of IIS from a sham-treated (1) and X-irradiated (2) mouse. For 1–2, the trace to the right shows an IIS at higher temporal resolution. Qualitatively, IIS were similar. 3. There was a higher IIS frequency in X-irradiated mice compared to sham-treated mice at all the time points tested.

C. 1–2. Representative examples of records from a X-irradiated and a sham-treated mouse at similar delays (approximately 7.5 hrs) after KA.

3. There were significantly more X-irradiated mice that exhibited delayed seizures compared to sham-treated mice. The mean number of seizures per mouse was greater in X-irradiated mice also.