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. Author manuscript; available in PMC: 2016 Mar 21.
Published in final edited form as: Exp Neurol. 2014 Dec 2;264:135–149. doi: 10.1016/j.expneurol.2014.11.009

Figure 5. In mice that were not pretreated with ethosuximide, GFAP-TK+ mice had a greater response to KA than GFAP-TK− mice.

Figure 5

A. The experimental timeline is shown for treatment of GFAP-TK mice with 16 mg/kg KA (GFAP-TK−, n = 13; GFAP-TK+, n = 14).

B. Representative examples of the response to KA in a GFAP-TK− and GFAP-TK+ mouse show a greater response in the GFAP-TK+ mouse.

C. 1–2. GFAP-TK+ mice had similar latencies to GFAP-TK+ mice for the first convulsive and first nonconvulsive seizure. 3. There were more convulsive seizures in GFAP-TK+ mice compared to GFAP-TK− mice. 4. The total duration of convulsive seizures was greater and total duration of nonconvulsive seizures was shorter in GFAP-TK+ mice compared to GFAP-TK− mice.

D. 1–2. Representative IIS in a GFAP-TK− and GFAP-TK+ mouse.

3. GFAP-TK+ mice had a higher IIS frequency than GFAP-TK− mice.