Table 3.

Multivariable Association between Grade-3 Primary Graft Dysfunction (PGD) and total volume of intraoperative fluids and its components (N =494)

Variables	PGD Grade ≥ 3 (N = 123)	PGD Grade 0–2 (N = 371)	Adjusted OR (95% CI)*	P value*
Total volume of intraoperative fluids (L)	5.0 [3.8,7.5]	3.9 [2.9,5.2]	1.22 (1.12, 1.34)	<0.001
Components of intraoperative fluids			99.2% CI
Volume of crystalloid solution (L)	3.0 [2.2, 4.0]	2.7 [2.1, 3.5]	1.0 (0.73, 1.37)	0.99
Volume of colloid solution (L)	0.3[0, 0.5]	0.3 [0, 0.5]	1.61(0.73, 3.60)	0.11
Volume of red blood cells (L) a	1.1 [0, 1.8]	0.4 [0, 1.1]	1.7 (1.08, 2.7)	0.002
Fresh frozen plasma (N of patients received, %)	54 (44)	84 (23)	0.99 (0.38, 2.53)	0.97
Platelet concentrate (N of patients received, %)	58 (47)	86 (23)	0.98 (0.39, 2.48)	0.96
Cryoprecipitate (N of patients received, %)	24 (20)	12 (3)	2.54 (0.68, 9.54)	0.06

Data are presented as mean ± SD, N (%), or median [25^th, 75^th percentiles].

^*CI – confidence interval; OR - odds ratio adjusted for the history of Idiopathic pulmonary hypertension, ischemia time, double lung transplant, use of cardiopulmonary bypass, average mean pulmonary artery pressure post-reperfusion, and average fraction of inspired oxygen post-reperfusion; N – number of patients Significance criterion for the total volume of intraoperative fluids was P < 0.05. As for the individual components of intraoperative fluids, P < 0.008 (Bonferroni correction, 0.05/6) was required to claim significance.

^a259 (54%) patients received red blood transfusion.