Table 3.
TCGA classifications of GBM based on transcription and methylation profiling
| Classifications | Subgroups | ||||
|---|---|---|---|---|---|
| Proneural | Neural | Classical | Mesenchymal | ||
| G-CIMP+ | G-CIMP− | ||||
| Genetic alteration | IDH/TP53/ATRX | 4q ampl. | 7p ampl. | NF1/RB1 | |
| Phenotype | Oligodendrocytic | Neuron | Astrocytic | Culture astroglial | |
| Prognosis | Best | Worst | Middle | ||
| Chemotherapy | Resistant | Response | Response | Response | |
TCGA: The cancer genome atlas; GBM: Glioblastoma; G-CIMP: Glioma-CpG island methylator phenotype; ampl.: Amplification; IDH: Isocitrate dehydrogenase; NF1: Neurofibromatosis 1; RB1: Retinoblastoma 1.