TABLE 4.
Antibiotic susceptibility of sagB mutant staphylococci
| S. aureus strain | MIC (μg/ml)a of: |
||||
|---|---|---|---|---|---|
| Flavomycin | Oxacillin | Vancomycin | Bacitracin | Nisin | |
| Newman strains | |||||
| Wild type | 6.250 | 0.2083 | 2.083 | 100.0 | 26.04 |
| atl strain | 8.125 | 0.5* | 2.188 | 166.7* | 23.44 |
| sagA strain | 6.563 | 0.2083 | 1.875 | 100.0 | 23.44 |
| sagB strain | 13.75† | 0.1042† | 3.750* | 50.00‡ | 23.44 |
| scaH strain | 6.250 | 0.25 | 1.875 | 100.0 | 26.04 |
| atl sagAB scaH strain | 30.00* | 0.4167* | 3.750* | 50.00‡ | 23.44 |
| USA300 strains | |||||
| Wild type | 6.667 | 5.416 | 2.500 | >1,000 | 11.72 |
| sagB strain | 8.611‡ | 3.125* | 4.583* | >1,000 | 15.63† |
a
The MIC of each antibiotic is the mean determined from at least three experiments performed in duplicate. Statistical significance was calculated by one-way ANOVA followed by Dunnett's test (Newman) or unpaired t test (USA300), as follows: †, P < 0.05; ‡, P < 0.01; *, P < 0.001.