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. Author manuscript; available in PMC: 2016 Mar 21.
Published in final edited form as: J Invest Dermatol. 2015 Jan 27;135(5):1338–1347. doi: 10.1038/jid.2015.20

Figure 4. Heteromeric HCs composed by Cx43 and the syndromic mutants produce large macroscopic currents.

Figure 4

Membrane currents from oocytes expressing Cx43 alone or Cx43 with Cx26 mutants were recorded using the two-electrode voltage clamp technique. HC currents were activated in response to depolarizing voltage steps from a holding potential of −10 mV, and stepped in 20 mV increments from −100 mV to + 60 mV. Representative currents traces are showed for hCx43 alone (a) or for hCx43 coexpressed with wild type Cx26 (b), hCx26G12V (c), hCx26G12R (d), hCx26N14Y (e) or Cx26S17F (f). (g) Graphic depicted the current voltage relationship of macroscopic heteromeric HCs. The data represent mean ± SEM of at least five independent experiments.