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. Author manuscript; available in PMC: 2016 Mar 21.
Published in final edited form as: Int J Oncol. 2000 May;16(5):971–978. doi: 10.3892/ijo.16.5.971

Figure 2.

Figure 2

The G2 checkpoint inhibition and potentiation of γ-irradiation-induced cytotoxicity by caffeine and eleven analogs. The G2 checkpoint inhibition (□) is expressed as the % G2-arrested cells induced to enter mitosis, as described in Materials and methods. The cytotoxicity of the compounds without γ-irradiation (○) is expressed as % cell survival compared with untreated controls. The cytotoxicity with γ-irradiation (●) is expressed as % cell survival compared with cells treated with 6 Gy irradiation alone. The 6 Gy irradiation induced about 80% cell death.