Table 2.
Comparison of Molecular Weights for the Homologous Proteins of Humans (H.s.) and Chimpanzees (P.t.).
| Parent gene | UniProt ID | Protein name | Reference | Mean isotopic mass of the H.s. protein | Mean m/z score of MS peak | Percent difference between mass of protein and m/z score | Percent difference between H.s. and P.t. peaks | ||
|---|---|---|---|---|---|---|---|---|---|
| H.s. | P.t. | H.s. | P.t. | ||||||
| NPY | NPY_HUMAN_1 | C-flanking protein of neuropeptide Y (CPON) | NA | 4272.72 | 4271.82 | 4271.94 | 0.021 | 0.018 | 0.003 |
| TMSB10 | TYB10_HUMAN | Thymosin beta-10 | 5 | 4894.48 | 4894.11 | 4894.00 | 0.007 | 0.010 | 0.002 |
| COX7C | COX7C_HUMAN | Cytochrome c oxidase subunit 7C, mitochondrial | 5 | 5356.25 | 5356.77 | 5357.03 | 0.010 | 0.015 | 0.005 |
| NDUFC1 | NDUC1_HUMAN | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | NA | 5937.89 | 5938.98 | 5941.49 | 0.018 | 0.061 | 0.042 |
| FAU | RS30_HUMAN | 40S ribosomal protein S30 | 1 | 6647.86 | 6649.40 | 6648.10 | 0.023 | 0.004 | 0.019 |
| COX7A2 | CX7A2_HUMAN | Cytochrome c oxidase subunit 7A2, mitochondrial | 2, 5 | 6721.81 | 6722.27 | 6721.09 | 0.007 | 0.011 | 0.018 |
| GNG10 | GBG10_HUMAN | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 | NA | 6907.93 | 6907.59 | 6908.18 | 0.005 | 0.004 | 0.009 |
| ATP5I | ATP5I_HUMAN | ATP synthase subunit e, mitochondrial | 1, 3, 4, 5 | 7802.02 | 7803.06 | 7803.75 | 0.013 | 0.022 | 0.009 |
| UBA52 | RL40_HUMAN | Ubiquitin-60S ribosomal protein L40 | 2, 3, 5 | 8564.84 | 8566.59 | 8567.51 | 0.020 | 0.031 | 0.011 |
| UQCRH | QCR6_HUMAN | Cytochrome b-c1 complex subunit 6, mitochondrial | 1 | 9246.09 | 9244.06 | 9244.97 | 0.022 | 0.012 | 0.010 |
| NDUFA4 | NDUA4_HUMAN | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 | 1, 3, 5 | 9369.86 | 9371.84 | 9372.08 | 0.021 | 0.024 | 0.003 |
| COX6A1 | CX6A1_HUMAN | Cytochrome c oxidase subunit 6A1, mitochondrial | NA | 9618.80 | 9620.20 | 9621.46 | 0.015 | 0.028 | 0.013 |
| UQCRQ | QCR8_HUMAN | Cytochrome b-c1 complex subunit 8 | 1, 5 | 9775.18 | 9778.30 | 9779.20 | 0.032 | 0.041 | 0.009 |
| SF3B5 | SF3B5_HUMAN | Splicing factor 3B subunit 5 | 1 | 10135.36 | 10136.39 | 10137.77 | 0.010 | 0.024 | 0.014 |
| SUMO3 | SUMO3_HUMAN | Small ubiquitin-related modifier 3 | 2 | 10524.83 | 10521.98 | 10523.81 | 0.027 | 0.010 | 0.017 |
| COX5B | COX5B_HUMAN | Cytochrome c oxidase subunit 5B, mitochondrial | 1, 2, 3, 5 | 10613.04 | 10613.60 | 10602.06 | 0.005 | 0.103 | 0.109 |
| CTSD | CATD_HUMAN_2 | Cathepsin D | 1, 3, 5 | 10679.98 | 10677.18 | 10678.77 | 0.026 | 0.011 | 0.015 |
| NDUFS6 | NDUS6_HUMAN | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | 3, 5 | 10698.97 | 10700.47 | 10702.45 | 0.014 | 0.033 | 0.019 |
| TXN | THIO_HUMAN | Thioredoxin | 1, 2, 4 | 11606.30 | 11606.29 | 11607.13 | 0.000 | 0.007 | 0.007 |
| GLRX | GLRX1_HUMAN | Glutaredoxin-1 | NA | 11644.55 | 11646.86 | 11649.30 | 0.020 | 0.041 | 0.021 |
| FKBP1A | FKB1A_HUMAN | Peptidyl-prolyl cis-trans isomerase FKBP1A | 1, 2 | 11819.51 | 11819.35 | 11820.20 | 0.001 | 0.006 | 0.007 |
| MIF | MIF_HUMAN | Macrophage migration inhibitory factor | 1, 5 | 12345.11 | 12345.59 | 12346.76 | 0.004 | 0.013 | 0.009 |
| NDUFS5 | NDUS5_HUMAN | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | 5 | 12386.31 | 12382.10 | 12381.12 | 0.034 | 0.042 | 0.008 |
| COX5A | COX5A_HUMAN | Cytochrome c oxidase subunit 5A, mitochondrial | 1, 2, 3, 5 | 12501.17 | 12501.82 | 12499.77 | 0.005 | 0.011 | 0.016 |
| SNRPD3 | SMD3_HUMAN | Small nuclear ribonucleoprotein Sm D3 | 1 | 13916.25 | 13913.40 | 13918.68 | 0.020 | 0.017 | 0.038 |
| HIST1H2AB | H2A1B_HUMAN | Histone H2A type 1-B/E | 3, 4 | 14004.30 | 14005.54 | 14004.55 | 0.009 | 0.002 | 0.007 |
| HBA1 | HBA_HUMAN | Hemoglobin subunit alpha | 1, 2, 3, 4, 5 | 15126.36 | 15127.12 | 15128.67 | 0.005 | 0.015 | 0.010 |
| PIRT | PIRT_HUMAN | Phosphoinositide-interacting protein | NA | 15334.40 | 15336.00 | 15336.75 | 0.010 | 0.015 | 0.005 |
| CRABP1 | RABP1_HUMAN | Cellular retinoic acid-binding protein 1 | NA | 15434.37 | 15435.19 | 15407.68 | 0.005 | 0.173 | 0.178 |
| HBB | HBB_HUMAN_1 | Hemoglobin subunit beta | 2, 3, 4 5 | 15867.22 | 15868.28 | 15869.90 | 0.007 | 0.017 | 0.010 |
| MRPL27 | RM27_HUMAN | 39S ribosomal protein L27, mitochondrial | 1 | 16072.81 | 16074.96 | 16076.99 | 0.013 | 0.026 | 0.013 |
| EIF5A2 | IF5A2_HUMAN | Eukaryotic translation initiation factor 5A-2 | NA | 16793.20 | 16788.45 | 16790.20 | 0.028 | 0.018 | 0.010 |
| RPL26 | RL26_HUMAN | 60S ribosomal protein L26 | 1 | 17258.21 | 17254.21 | 17255.65 | 0.023 | 0.015 | 0.008 |
| PPIA | PPIA_HUMAN | Peptidyl-prolyl cis-trans isomerase A | 1, 2, 5 | 17881.30 | 17883.59 | 17842.11 | 0.013 | 0.219 | 0.232 |
| ACP1 | PPAC_HUMAN | Low molecular weight phosphotyrosine protein phosphatase | 1, 4 | 17911.29 | 17917.88 | 17923.80 | 0.037 | 0.070 | 0.033 |
| SKP1 | SKP1_HUMAN | S-phase kinase-associated protein 1 | 1, 2, 5 | 18526.81 | 18523.54 | 18528.19 | 0.018 | 0.007 | 0.025 |
| PMS2P3 | PM2P3_HUMAN | Putative postmeiotic segregation increased 2-like protein 3 | NA | 18715.80 | 18717.68 | 18726.45 | 0.010 | 0.057 | 0.047 |
| PEBP1 | PEBP1_HUMAN | Phosphatidylethanolamine-binding protein 1 | 1, 2, 3, 4, 5 | 20925.59 | 20918.62 | 20920.44 | 0.033 | 0.025 | 0.009 |
| MYL6B | MYL6B_HUMAN | Myosin light chain 6B | NA | 22763.99 | 22763.36 | 22739.00 | 0.003 | 0.110 | 0.107 |
| NPY | NPY_HUMAN_1 | Neuropeptide Y | NA | 4272.72 | 4271.82 | 4271.94 | 0.021 | 0.018 | 0.003 |
| TMSB10 | TYB10_HUMAN | Thymosin beta-10 | 5 | 4894.48 | 4894.11 | 4894.00 | 0.007 | 0.010 | 0.002 |
| COX7C | COX7C_HUMAN | Cytochrome c oxidase subunit 7C, mitochondrial | 5 | 5356.25 | 5356.77 | 5357.03 | 0.010 | 0.015 | 0.005 |
| NDUFC1 | NDUC1_HUMAN | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | NA | 5937.89 | 5938.98 | 5941.49 | 0.018 | 0.061 | 0.042 |