Table 2.
Age-adjusted incidence rates*, incidence rate ratios (IRRs), and 95% confidence intervals (CIs), of classical Hodgkin lymphoma and selected histologic subtypes, by ethnic enclave tertile, Hispanics, California, 1988-92/1998-02
| Characteristics | Hispanic Enclave§ | All classical Hodgkin lymphoma | Nodular sclerosis | Mixed cellularity | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Male | Female | Male | Female | Male | Female | ||||||||||||||
| N = 812 | N = 651 | N = 432 | N = 445 | N = 225 | N = 105 | ||||||||||||||
| N | Rate* (95% CI) | IRR (95% CI) | N | Rate* (95% CI) | IRR (95% CI) | N | Rate* (95% CI) | IRR (95% CI) | N | Rate* (95% CI) | IRR (95% CI) | N | Rate* (95% CI) | IRR (95% CI) | N | Rate* (95% CI) | IRR (95% CI) | ||
| ALL COMBINED | |||||||||||||||||||
| More ethnic | 354 | 2.35 (2.02-2.71) | 1.00 (reference) | 249 | 1.40 (1.21-1.62) | 1.00 (reference) | 181 | 0.93 (0.75-1.15) | 1.00 (reference) | 175 | 0.87 (0.72-1.04) | 1.00 (reference) | 109 | 0.86 (0.66-1.11) | 1.00 (reference) | 39 | 0.30 (0.20-0.42) | 1.00 (reference) | |
| Intermediate | 190 | 2.30 (1.89-2.76) | 0.98 (0.77-1.24) | 154 | 1.69 (1.40-2.03) | 1.20 (0.94-1.53) | 92 | 0.93 (0.69-1.24) | 1.00 (0.69-1.43) | 100 | 0.90 (0.71-1.12) | 1.03 (0.77-1.39) | 53 | 0.71 (0.49-0.99) | 0.82 (0.52-1.27) | 30 | 0.42 (0.27-0.61) | 1.39 (0.79-2.42) | |
| Less ethnic | 268 | 2.63 (2.26-3.04) | 1.12 (0.91-1.38) | 248 | 2.30 (1.99-2.64) | 1.64 (1.33-2.02) | 159 | 1.23 (1.02-1.47) | 1.31 (0.99-1.75) | 170 | 1.36 (1.15-1.61) | 1.57 (1.22-2.01) | 63 | 0.82 (0.60-1.10) | 0.95 (0.63-1.42) | 36 | 0.44 (0.30-0.62) | 1.46 (0.86-2.46) | |
| AGE GROUP AT DIAGNOSIS | |||||||||||||||||||
| 00-14 years | More ethnic | 65 | 0.92 (0.71-1.17) | 1.00 (reference) | 27 | 0.43 (0.29-0.63) | 1.00 (reference) | 39 | 0.56 (0.40-0.76) | 1.00 (reference) | 23 | 0.37 (0.23-0.55) | 1.00 (reference) | 21 | 0.28 (0.18-0.44) | 1.00 (reference) | -- | -- | -- |
| Intermediate | 24 | 0.69 (0.44-1.03) | 0.76 (0.45-1.22) | 16 | 0.49 (0.28-0.79) | 1.12 (0.57-2.16) | 13 | 0.38 (0.20-0.65) | 0.69 (0.34-1.31) | 12 | 0.37 (0.19-0.64) | 1.00 (0.45-2.08) | 9 | 0.26 (0.12-0.49) | 0.91 (0.36-2.07) | -- | -- | -- | |
| Less ethnic | 22 | 0.62 (0.39-0.93) | 0.67 (0.39-1.11) | 18 | 0.54 (0.32-0.85) | 1.25 (0.65-2.35) | 15 | 0.42 (0.23-0.69) | 0.75 (0.39-1.40) | 13 | 0.39 (0.21-0.67) | 1.07 (0.50-2.19) | -- | -- | -- | -- | -- | -- | |
| 15-39 years | More ethnic | 167 | 1.43 (1.22-1.68) | 1.00 (reference) | 143 | 1.44 (1.21-1.70) | 1.00 (reference) | 102 | 0.86 (0.70-1.04) | 1.00 (reference) | 118 | 1.19 (0.98-1.43) | 1.00 (reference) | 40 | 0.35 (0.24-0.48) | 1.00 (reference) | 11 | 0.11 (0.06-0.21) | 1.00 (reference) |
| Intermediate | 96 | 1.71 (1.38-2.09) | 1.19 (0.91-1.55) | 83 | 1.63 (1.29-2.03) | 1.13 (0.85-1.50) | 58 | 1.06 (0.80-1.37) | 1.23 (0.87-1.73) | 67 | 1.30 (1.00-1.66) | 1.10 (0.80-1.50) | 20 | 0.35 (0.21-0.54) | 1.00 (0.55-1.77) | 9 | 0.19 (0.09-0.36) | 1.66 (0.60-4.46) | |
| Less ethnic | 143 | 2.26 (1.90-2.67) | 1.58 (1.25-1.99) | 144 | 2.61 (2.20-3.08) | 1.81 (1.42-2.31) | 106 | 1.69 (1.38-2.05) | 1.97 (1.48-2.62) | 117 | 2.11 (1.75-2.54) | 1.78 (1.36-2.33) | 19 | 0.30 (0.18-0.47) | 0.87 (0.47-1.55) | 9 | 0.18 (0.08-0.33) | 1.55 (0.56-4.16) | |
| 40-54 years | More ethnic | 41 | 1.53 (1.10-2.09) | 1.00 (reference) | 25 | 0.91 (0.59-1.34) | 1.00 (reference) | 15 | 0.54 (0.30-0.89) | 1.00 (reference) | 13 | 0.49 (0.26-0.84) | 1.00 (reference) | 15 | 0.56 (0.31-0.93) | 1.00 (reference) | -- | -- | -- |
| Intermediate | 30 | 1.91 (1.28-2.74) | 1.24 (0.75-2.05) | 23 | 1.48 (0.94-2.23) | 1.63 (0.88-3.01) | 11 | 0.67 (0.33-1.22) | 1.25 (0.52-2.97) | 10 | 0.63 (0.30-1.16) | 1.27 (0.50-3.17) | 10 | 0.69 (0.33-1.27) | 1.23 (0.49-2.93) | 8 | 0.55 (0.24-1.08) | 4.25 (1.11-19.24) | |
| Less ethnic | 47 | 2.48 (1.82-3.31) | 1.62 (1.04-2.53) | 33 | 1.65 (1.13-2.33) | 1.82 (1.05-3.21) | 22 | 1.13 (0.71-1.72) | 2.10 (1.03-4.42) | 23 | 1.12 (0.71-1.69) | 2.28 (1.11-4.95) | 17 | 0.90 (0.52-1.44) | 1.59 (0.74-3.44) | 7 | 0.39 (0.15-0.79) | 2.98 (0.74-13.87) | |
| 55+ years | More ethnic | 81 | 6.13 (4.78-7.75) | 1.00 (reference) | 54 | 2.81 (2.09-3.71) | 1.00 (reference) | 25 | 1.84 (1.14-2.81) | 1.00 (reference) | 21 | 1.23 (0.75-1.90) | 1.00 (reference) | 33 | 2.61 (1.74-3.76) | 1.00 (reference) | 21 | 1.03 (0.63-1.60) | 1.00 (reference) |
| Intermediate | 40 | 5.27 (3.65-7.36) | 0.86 (0.55-1.31) | 32 | 3.21 (2.17-4.57) | 1.14 (0.70-1.82) | 10 | 1.55 (0.69-2.96) | 0.84 (0.33-1.92) | 11 | 1.04 (0.51-1.89) | 0.85 (0.36-1.89) | 14 | 1.78 (0.93-3.11) | 0.68 (0.32-1.38) | 10 | 0.99 (0.46-1.84) | 0.96 (0.39-2.18) | |
| Less ethnic | 56 | 5.40 (4.01-7.15) | 0.88 (0.60-1.29) | 53 | 4.21 (3.13-5.54) | 1.50 (0.99-2.25) | 16 | 1.37 (0.77-2.32) | 0.74 (0.36-1.55) | 17 | 1.33 (0.76-2.14) | 1.08 (0.53-2.20) | 23 | 2.33 (1.41-3.62) | 0.89 (0.48-1.64) | 16 | 1.23 (0.69-2.03) | 1.20 (0.57-2.46) | |
| NEIGHBORHOOD SES‡ | |||||||||||||||||||
| Low | More ethnic | 309 | 2.25 (1.92-2.63) | 1.00 (reference) | 214 | 1.31 (1.11-1.53) | 1.00 (reference) | 163 | 0.94 (0.74-1.17) | 1.00 (reference) | 151 | 0.83 (0.67-1.00) | 1.00 (reference) | 92 | 0.79 (0.59-1.03) | 1.00 (reference) | 31 | 0.24 (0.16-0.36) | 1.00 (reference) |
| Intermediate | 87 | 2.36 (1.75-3.11) | 1.05 (0.75-1.45) | 58 | 1.73 (1.24-2.33) | 1.32 (0.91-1.86) | 43 | 1.03 (0.64-1.56) | 1.09 (0.65-1.77) | 32 | 0.71 (0.46-1.06) | 0.86 (0.53-1.35) | 25 | 0.77 (0.43-1.26) | 0.97 (0.51-1.74) | 15 | 0.55 (0.28-0.95) | 2.27 (1.04-4.64) | |
| Less ethnic | 42 | 2.49 (1.62-3.66) | 1.11 (0.70-1.68) | 38 | 2.12 (1.39-3.08) | 1.62 (1.03-2.45) | 22 | 0.95 (0.56-1.59) | 1.01 (0.56-1.79) | 28 | 1.30 (0.78-2.04) | 1.57 (0.91-2.60) | 12 | 0.93 (0.40-1.81) | 1.18 (0.48-2.46) | 5 | 0.35 (0.11-0.87) | 1.46 (0.40-4.08) | |
| High | More ethnic | 45 | 3.18 (2.06-4.66) | 1.00 (reference) | 35 | 2.23 (1.48-3.22) | 1.00 (reference) | 18 | 0.87 (0.46-1.57) | 1.00 (reference) | 24 | 1.28 (0.76-2.03) | 1.00 (reference) | 17 | 1.53 (0.69-2.82) | 1.00 (reference) | 8 | 0.75 (0.31-1.47) | 1.00 (reference) |
| Intermediate | 103 | 2.23 (1.71-2.87) | 0.70 (0.44-1.16) | 96 | 1.69 (1.33-2.12) | 0.76 (0.49-1.22) | 49 | 0.86 (0.56-1.25) | 0.99 (0.47-2.09) | 68 | 1.04 (0.78-1.36) | 0.81 (0.47-1.47) | 28 | 0.66 (0.40-1.03) | 0.43 (0.19-1.09) | 15 | 0.33 (0.17-0.56) | 0.44 (0.17-1.24) | |
| Less ethnic | 226 | 2.65 (2.25-3.10) | 0.83 (0.55-1.32) | 210 | 2.34 (2.00-2.71) | 1.05 (0.70-1.62) | 137 | 1.29 (1.05-1.57) | 1.48 (0.79-2.89) | 142 | 1.37 (1.14-1.63) | 1.07 (0.65-1.86) | 51 | 0.80 (0.56-1.10) | 0.52 (0.25-1.23) | 31 | 0.45 (0.30-0.65) | 0.60 (0.27-1.56) | |
| ENCLAVE*SES‡ | |||||||||||||||||||
| More Ethnic/Low SES | 309 | 2.25 (1.92-2.63) | 1.00 (reference) | 214 | 1.31 (1.11-1.53) | 1.00 (reference) | 163 | 0.94 (0.74-1.17) | 1.00 (reference) | 151 | 0.83 (0.67-1.00) | 1.00 (reference) | 92 | 0.79 (0.59-1.03) | 1.00 (reference) | 31 | 0.24 (0.16-0.36) | 1.00 (reference) | |
| More Ethnic/High SES | 45 | 3.18 (2.06-4.66) | 1.41 (0.89-2.14) | 35 | 2.23 (1.48-3.22) | 1.70 (1.10-2.56) | 18 | 0.87 (0.46-1.57) | 0.93 (0.47-1.76) | 24 | 1.28 (0.76-2.03) | 1.55 (0.89-2.58) | 17 | 1.53 (0.69-2.82) | 1.94 (0.84-3.85) | 8 | 0.75 (0.31-1.47) | 3.08 (1.18-7.02) | |
| Intermediate/Low SES | 87 | 2.36 (1.75-3.11) | 1.05 (0.75-1.45) | 58 | 1.73 (1.24-2.33) | 1.32 (0.91-1.86) | 43 | 1.03 (0.64-1.56) | 1.09 (0.65-1.77) | 32 | 0.71 (0.46-1.06) | 0.86 (0.53-1.35) | 25 | 0.77 (0.43-1.26) | 0.97 (0.51-1.74) | 15 | 0.55 (0.28-0.95) | 2.27 (1.04-4.64) | |
| Intermediate/High SES | 103 | 2.23 (1.71-2.87) | 0.99 (0.73-1.34) | 96 | 1.69 (1.33-2.12) | 1.29 (0.97-1.72) | 49 | 0.86 (0.56-1.25) | 0.91 (0.57-1.43) | 68 | 1.04 (0.78-1.36) | 1.26 (0.89-1.78) | 28 | 0.66 (0.40-1.03) | 0.84 (0.47-1.44) | -- | -- | -- | |
| Less Ethnic/Low SES | 42 | 2.49 (1.62-3.66) | 1.11 (0.70-1.68) | 38 | 2.12 (1.39-3.08) | 1.62 (1.03-2.45) | 22 | 0.95 (0.56-1.59) | 1.01 (0.56-1.79) | 28 | 1.30 (0.78-2.04) | 1.57 (0.91-2.60) | 12 | 0.93 (0.40-1.81) | 1.18 (0.48-2.46) | -- | -- | -- | |
| Less Ethnic/High SES | 226 | 2.65 (2.25-3.10) | 1.18 (0.94-1.48) | 210 | 2.34 (2.00-2.71) | 1.79 (1.43-2.24) | 137 | 1.29 (1.05-1.57) | 1.37 (1.01-1.87) | 142 | 1.37 (1.14-1.63) | 1.66 (1.26-2.17) | 51 | 0.80 (0.56-1.10) | 1.01 (0.64-1.57) | 31 | 0.45 (0.30-0.65) | 1.86 (1.03-3.35) | |
*
Per 100,000 person-years and standardized to the 2000 U.S. standard population
§
More ethnic (Enclave Quintile 5); Intermediate (Enclave Quintile 4); Less ethnic (Enclave Quintile 1-3)
--Per confidentiality regulations of the California Cancer Registry, case counts and rates based on fewer than 5 cases are suppressed, and statistics are not computed.
‡
Low SES comprises the lowest SES tertile; high SES comprises the middle and highest SES tertiles.
Bolding denotes statistical significance.