Table 1.
In vitro growth inhibitory activity of BS-181 on gastric cancer and normal cell lines
| Cell lines | Differentiation | IC50, μM (SD)a |
|---|---|---|
| MKN28 | Well differentiated | 16.8 (4.2) |
| SGC-7901 | Moderately differentiated | 19.2 (5.5) |
| AGS | Poorly differentiated | 21.2 (6.1) |
| BGC823 | Undifferentiated | 22.4 (5.0) |
| RGM-1 | Normal gastric epithelial cells | 6.5 (1.5) |
Notes: Different gastric cancer cell lines including MKN28, SGC-7901, AGS, and BGC823 were treated with increasing concentrations of BS-181 for 48 hours. CCK-8 assay showed that gastric cancer cell growth was inhibited by BS-181, with IC50 ranging from 17 μM to 22 μM;
a
tested by CCK-8 assay.
Abbreviations: IC50, inhibitory concentration; SD, standard deviation.