Table 2.
Inhibition of cyclin-dependent protein kinase activity by BS-181
| Kinases | Roscovitine IC50, μM (SD) | BS-181 IC50, μM (SD) |
|---|---|---|
| CDK7 | 0.48 (0.12) | 0.019 (0.005) |
| CDK1 | 1.50 (0.31) | 6.70 (2.1) |
| CDK2 | 0.09 (0.02) | 1.01 (0.32) |
| CDK4 | 16.2 (3.50) | 27.0 (4.4) |
| CDK5 | 0.20 (0.06) | 3.60 (0.62) |
| CDK6 | 24.5 (5.20) | 32.5 (6.7) |
| CDK9 | 1.05 (0.34) | 4.2 (1.1) |
Notes: The mean IC50 values (μM) for roscovitine and BS-181 were obtained from three independent experiments. Roscovitine is a potent and selective CDK inhibitor. Data are expressed as mean ± SD.
Abbreviations: IC50, inhibitory concentration; SD, standard deviation; CDK, cyclin- dependent kinase.