Table 2. Hazard Ratio for cases compared to non-cases unadjusted and adjusted for variables shown.

Variable adjusted for	Categories or five number summary	Number of individuals or value	HR	95% CI	p-value
None (unadjusted)	Case	100	2.33	1.63–3.32	<0.001
	Non-case	98
Age a	Number	198	1.46	1.01–2.10	0.04
	Minimum	19
	25th centile	70
	Median	80.5
	75th centile	86
	Maximum	98
Sex a	Male	87	2.30	1.61–3.29	<0.001
	Female	111
Year of admission	2005	65	2.30	1.61–3.28	<0.001
	2006	67
	2007	66
Month of admission	January	24	2.34	1.59–3.44	<0.001
	February	22
	March	24
	April	18
	May	14
	June	11
	July	16
	August	18
	September	17
	October	11
	November	11
	December	12
Place admitted from b	Own home	160	2.20	1.53–3.17	<0.001
	Residential care	29
	Another hospital	3
	Other	4
Malignancy diagnosis at index admission a	Yes	31	2.39	1.67–3.40	<0.001
	No	167
Infection diagnosis other than Clostridium difficile at index admission b	Yes	84	2.29	1.55–3.67	<0.001
	No	114
Charlson Comorbidity index a	Number	198	2.24	1.57–3.19	<0.001
	Minimum	0
	25th centile	0
	Median	2
	75th centile	3
	Maximum	12
Immune compromised condition at index admission b	Yes	23	2.27	1.59–3.25	<0.001
	No	173
Haemoglobin g/dL b	Number	180	2.14	1.46–3.13	<0.001
	Minimum	5.6
	25th centile	10.6
	Median	12.1
	75th centile	13.6
	Maximum	19.4
Total White Cell count 109/L	Number	166	2.43	1.65–3.57	<0.001
	Minimum	3.1
	25th centile	7.7
	Median	10.9
	75th centile	14.3
	Maximum	66.3
Blood Glucose mmol/L	Number	62	1.64	0.87–3.08	0.12
	Minimum	1.7
	25th centile	5.6
	median	7.0
	75th centile	9.4
	Maximum	70
Serum Creatinine umol/L	Number	161	2.28	1.54–3.37	<0.001
	Minimum	5
	25th centile	72
	Median	90
	75th centile	128
	Maximum	512
Serum Urea mmol/L b	Number	145	2.27	1.50–3.44	<0.001
	Minimum	2.0
	25th centile	5.5
	Median	8.0
	75th centile	14.1
	Maximum	130.0
Fever≥ 38 C during Index admission b	Yes	31	2.52	1.74–3.66	<0.001
	No	155
Systolic Blood pressure ≤ 100 mmHg	Yes	31	2.45	1.70–3.58	<0.001
	No	164
Clinical diagnosis of sepsis	Yes	15	2.41	1.68–3.47	<0.001
	No	183
Positive blood culture	Yes	1	2.32	1.62–3.31	<0.001
	No	197
Smoking History b	Current smoker	23	2.89	1.79–4.66	<0.001
	Past smoker	46
	Never smoker	61
Type of alcoholic drinker	Heavy	4	2.13	1.49–3.06	<0.001
	Drinker but not heavy	156
	Non-drinker	38
Surgery during index admission b	Yes	51	2.50	1.75–3.57	<0.001
	No	145
Nasogastric tube inserted during index admissiona	Yes	28	2.30	1.58–3.33	<0.001
	No	167
Procedure other than surgery during index admission	Yes	69	2.27	1.55–3.35	<0.001
	No	124
IMD score	Number	198	2.37	1.66–3.39	<0.001
	Minimum	0.7
	25th centile	6.5
	Median	9.6
	75th centile	14.4
	Maximum	32.1

^a indicates variables included in the final multivariable Cox Regression model

^b indicates variables considered in stepwise multivariable survival modelling but excluded from the final Cox Regression model