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Mechanisms involved in hyperglycemia in T2D and site of action of metformin and dapagliflozin.
Note: Through direct and indirect mechanisms, combination therapy with metformin and dapagliflozin may reduce hyperglycemia via effects on several of these pathways.
Abbreviations: GI, gastrointestinal; GLP-1, glucagon-like peptide-1; T2D, type 2 diabetes.
