Fig. 3.

Surface coil MR images of AβPP/PS1 mouse brain at 9.4T. A) One of thirty, 120 μm thick, slices from an AβPP/PS1 mouse brain untreated with SPIONs, which demonstrated the MR imaging of plaques without the aid of a contrast agent. This brain contained 355 plaques whose Z-scores exceeded 2.5. The mean Z-score for this brain was 4.6 (See Fig. 4A–C for the 3D plaque distribution for this brain). B) One of thirty, 120 μm thick, slices from the brain of an AβPP/PS1 transgenic mouse that was treated with the injection of anti-AβPP conjugated SPIONs for 24 h and then sacrificed. Note how the SPIONs enhanced the conspicuity of the plaques. The mean Z-score for this brain was 8.0 (See Fig. 4D–F for the 3D plaque distribution for this brain).