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The Z-loop inhibits TLR8 dimerization. (A) Superposition of TLR8Z-loop (green) and unliganded TLR8wt dimer (gray) structures. (B) Close-up view of LRR14–LRR18 in TLR8Z-loop (green) superimposed on unliganded TLR8wt dimer (gray) in Cɑ trace models. (C) Close-up view of LRR8–LRR11 TLR8Z-loop (green) superimposed on liganded TLR8wt dimer (blue, TLR8/CL097) in Cɑ trace models. The CL097 molecule is shown in a space-filling representation.
