Table S1.
Summary of metabolic function, rationale for selection, and nuclear interactors of candidate proteins (www.yeastgenome.org; 19)
| Candidate | Metabolic function | Rationale | Examples of nuclear interactors |
| Adh5 | Alcohol dehydrogenase | NAD+ homeostasis | Nab2, Npl3 (nuclear RNA binding) |
| Arg82 | Transcriptional activation; inositol polyphosphate kinase | Kinase activity | Hir1,Hir2, Hir3 (HIR complex) |
| Rad53 (DNA damage response) | |||
| Yaf9 (shared subunit of NuA4 and Swr1 complexes) | |||
| Fpr1 | Prolyl-isomerase | Prolyl-isomerase activity | Cdc73 (Paf1 complex) |
| Gcn5 (shared subunit of ADA and SAGA complex) | |||
| Hmo1 (HMG family) | |||
| H2A.Z | |||
| Gdh1 | Glutamate dehydrogenase | NAD(P)+ and α-ketoglutarate homeostasis | Ceg1, Cet1 (nuclear RNA binding proteins) |
| Ess1 (nuclear prolyl-isomerase) | |||
| Gdh3 | |||
| Gdh3 | Glutamate dehydrogenase | NAD(P)+ and α-ketoglutarate homeostasis | Gdh1 |
| Htl1(Rsc complex) | |||
| YEL057C (unknown protein in telomere maintenance) | |||
| Hom2 | Methionine–threonine biosynthesis | NAD(P)+ homeostasis | Cdc13 (telomere binding protein) |
| Seh1 and Sec13 (Nup84 complex) | |||
| Hom6 | Methionine–threonine biosynthesis | NAD(P)+ homeostasis | Eaf1, Esa1 (NuA4 complex) |
| Nat1 Histone H3, H2A.Z | |||
| Ard1 (NatA complex) | |||
| Rad50, Mre11 (MRX complex) | |||
| Rad51, Rad52, Rad54, Rad55, and Rad57 (homologous end repair) | |||
| Hpa3 | d-amino acid N-acetyltransferase | Acetyl-CoA | Asa1 (ASTRA chromatin remodeling complex) |
| Nab2, Npl3 (nuclear RNA binding) | |||
| Sam4 | SAM-homocysteine methyltransferase | SAM homeostasis | Sif2 (Set3C complex) |
| Slx5 (STUbL) | |||
| Ser2 | Phosphoserine phosphatase for the phosphoglycerate pathway | Phosphatase activity | Ard1, Nat1 (NatA complex) |
| Cse2, Med1, Srb8 (mediator complex) | |||
| Eaf1 (NuA4 complex) | |||
| Spe2 | SAM decarboxylase | SAM homeostasis | Cdc13 (telomere binding) |
| Histone H2A and H2B | |||
| Rad4, Rtt109 (DNA damage repair) | |||
| Rpd3 | |||
| Utr4 | Enolase phosphatase | Phosphatase activity | Asf1 (nucleosome assembly) |
| Nab2 (nuclear RNA binding) | |||
| Swc4 (Swr1 complex) |