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Pairwise structural alignment of unliganded hTRAP1N with known crystal structures of full-length Hsp90. Only the N domains are shown. (A) Zebrafish TRAP1-ADPNP dimer (PDB ID code 4IPE) (21). (B) Yeast Hsp90-ATP dimer (PDB ID code 2CG9) (20). (C) Canine Grp94-ADPNP (PDB ID code 2O1U) (33). (D) Bacterial Hsp90-apo (HtpG) (PDB ID code 2IOQ) (18).
