Table S1.

Compounds that produced a statistically significant change in FAIRE signal

Plate	FAIRE signal	Target category	Chemical category	No. of hit compounds
1	Decrease	Methyl lysine reader	Uncharacterized	8
		DNA methyltransferase	Chemical probe	1
		Lysine methyltransferase	Uncharacterized	16
	Increase	Methyl lysine reader	Uncharacterized	6
		Lysine methyltransferase	Uncharacterized	6
2	Decrease	Histone deacetylase	Chemical probe (Table S2)	14
		Methyl lysine reader	Uncharacterized	10
		Lysine methyltransferase	Uncharacterized	6
		Arginine methyltransferase	Uncharacterized	3
	Increase	Methyl lysine reader	Uncharacterized	5
		Lysine methyltransferase	Uncharacterized	3

Hit compounds, their effect on FAIRE signal, and the number in each target category are listed.