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Pancreatic disease increases ATF3 in sensory afferents. (A) Nuclear localization of ATF3 immunoreactivity in DRG (Top) and nodose ganglia (Bottom) of PKCT mice at the PanIN stage. (B) ATF3 is also elevated in celiac ganglia of PKCY mice. (C) H&E staining shows ATF3-IR in neurons of nodose and celiac ganglia. (D) Summary of increases in neuronal ATF3 expression in sensory and autonomic ganglia during PanIN and cancer stages. *P < 0.05, **P < 0.01, n = 7 per group. (Scale bar, 100 µm.)
