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Fusing CD4 to Lck reveals responses to null pMHCII. (A) 58α−β− cells expressing the 5c.c7 TCR plus the indicated CD4 molecules were co-cultured with M12 cells expressing the indicated tethered peptide:I-Ek. (B) 58α−β− cells expressing the OT-II TCR and the indicated CD4 molecule were co-cultured with M12 cells expressing the indicated tethered peptide:I-Ab constructs. Data are representative of two experiments (mean ± SEM of triplicate wells). IL-2 was measured by ELISA at 16 h.
