Fig. 4.

Peptide-independent TCR interactions with nonselecting MHCII. 58α⁻β⁻ cells expressing (A) 5c.c7 or (B) OT-II TCRs plus the indicated CD4 molecules were co-cultured with M12 cells expressing tethered pMHCII as labeled. Experiments were performed and are labeled as in Fig. 3. Data are representative of two experiments.