Fig. 2.

DIM-7 regulates LTM during consolidation. (A) The time window for DIM-7 effects is confined to the period after completion of spaced training. The drug (RU486) feeding (RU+ vs. RU−) regimens are depicted (Top). Genotypes are shown in the Middle. Spaced-training–induced 24-h LTM is presented in the Bottom of the histogram. RU486 feeding (RU+) after training (A3) was sufficient to affect 24-h LTM. (B) Effective within the period of consolidation. For 48-h LTM, RU486 feeding (RU+) was sufficient in the first 24 h after spaced training (B1), but insufficient in the last 24 h (for retrieval; B2). Bars, mean ± SEM (n = 8); *P < 0.05.