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. 2016 Feb 22;113(11):E1536–E1544. doi: 10.1073/pnas.1600039113

Fig. 6.

Fig. 6.

PER3−/− mice demonstrate depression-like behavior in short photoperiods. (A) Duration of immobility of WT vs. Per3−/− mice in the tail suspension test under LD 12:12 and LD 4:20. (B and C) Latency to immobilization (B) and duration of immobility (C) of WT vs. Per3−/− mice in the forced swim test under LD 12:12 and LD 4:20. (D) Treatment with imipramine (20 mg/kg i.p.) rescues the tail suspension phenotype in Per3−/− mice under LD 4:20. Error bars show mean ± SEM (n = 6 per group). (E) Treatment with imipramine (20 mg/kg i.p.) rescues the forced swim phenotype in Per3−/− mice under LD 4:20. Error bars represent mean ± SEM (n = 6 each genotype). (F) Amount of sucrose water intake in WT and Per3−/− mice under LD 4:20. Error bars represent mean ± SEM (n = 4–22). *P < 0.05, **P < 0.01, ***P < 0.005, Student’s t test.