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. 2016 Mar 21;11(3):e0151515. doi: 10.1371/journal.pone.0151515

Fig 4. MEF2-dependent regulation of the Gtl2-Dio3 proximal promoter and miRNAs in cardiac homeostasis and stress.

Fig 4

A, Luciferase analysis of the wild type (WT) and MEF2 site mutant (MUT) Gtl2-Dio3 proximal promoter in neonatal cardiomyocytes stimulated with PE or Ang II compared to control (PBS). B, Quantitative RT-PCR expression of miR-410 and miR-495 in control (shlacZ) and MEF2A depleted (shMef2a) NRVMs treated with PE or Ang II, respectively. C, Quantitative RT-PCR expression of miR-410 and miR-495 in adult MEF2A knockout hearts. D, Quantitative RT-PCR expression of miR-410 and miR-495 in NRVMs depleted of MEF2A (shMef2a), MEF2D (shMef2d), or both (shMef2a/d) compared to control (shlacZ). Error bars represent mean ± S.E. *, p<0.05; **, p<0.01; ***, p<0.001.