Table 3.
Pseudokinase domain divergence. Of the 48 known human pseudokinase catalytic domains, 22 have various degrees of identity to zebrafish proteins. Pseudokinases with no clear homologous non-redundant partner are left unmatched. Modified critical Hanks domains (DFG, HRD, or VIAK) are indicated based on Boudeau and colleagues [17] and alignment of the matching pairs.
| Human pseudokinase |
Modified domains | % identity | Zebrafish pseudokinase |
Modified domains |
|---|---|---|---|---|
| ANPA | HRD | 84 | NPR1A | HRD |
| ANPB | HRD | -- | -- | -- |
| CASK | DFG | 99 | CASKA | DFG |
| CCK4 | DFG | -- | -- | -- |
| CYGD | HRD | 60 | GC3 | HRD |
| CYGF | HRD | 77 | GC2 | HRD |
| EPHA10 | DFG, HRD, VIAK | -- | -- | -- |
| EPHB6 | DFG, HRD, VIAK | -- | -- | -- |
| GCN2-P | HRD, VIAK | -- | -- | -- |
| HER3 (ERBB3) | HRD | 75 | ERBB3A | HRD |
| HSER | HRD | -- | -- | -- |
| ILK | DFG, HRD | 86 | ILK | DFG, HRD |
| IRAK2 | DFG, HRD | -- | -- | -- |
| JAK1-P | HRD | 70 | JAK1-P | HRD |
| JAK2-P | HRD | 83 | JAK2B-P | HRD |
| JAK3-P | HRD | 60 | JAK3-P | HRD |
| KSR1 | VIAK | -- | -- | -- |
| KSR2 | VIAK | 88 | KSR2 | VIAK |
| MLKL | DFG, HRD | -- | -- | -- |
| NRBP1 | DFG, HRD, VIAK | 95 | NRBP1 | DFG, HRD, VIAK |
| NRBP2 | DFG, HRD, VIAK | -- | -- | -- |
| PSKH2 | HRD | -- | -- | -- |
| RSKL1 | DFG, VIAK | -- | -- | -- |
| RSKL2 | DFG, VIAK | -- | -- | -- |
| SCYL1 | DFG, HRD, VIAK | -- | -- | -- |
| SCYL2 | DFG, HRD, VIAK | 89 | SICH211-244B2.1 | DFG, HRD, VIAK |
| SCYL3 | DFG, HRD, VIAK | 73 | SCYL3 | DFG, HRD, VIAK |
| SGK071 | HRD | -- | -- | -- |
| SGK196 | DFG, HRD, VIAK | 60 | POMK | DFG, HRD, VIAK |
| SGK223 | DFG | -- | -- | -- |
| SGK269 | DFG | -- | -- | -- |
| SGK307 | DFG, HRD | -- | -- | -- |
| SGK396 | HRD | -- | -- | -- |
| SGK494 | DFG, HRD, VIAK | 59 | SGK494A | NONE |
| SGK495 | DFG | -- | -- | -- |
| SLOB | DFG, HRD, VIAK | -- | -- | -- |
| STLK5 (STRADA) | DFG, HRD, VIAK | 72 | STRADA | DFG, HRD, VIAK |
| STKL6 (STRADB) | DFG, HRD | -- | -- | -- |
| SURTK106 | DFG | -- | -- | -- |
| TBCK | DFG, HRD, VIAK | 62 | TBCK | DFG, HRD, VIAK |
| TRB1 | DFG | 55 | TRIB1 | HRD, VIAK |
| TRB2 | DFG | 58 | TRIB3 | DFG, HRD, VIAK |
| TRB3 | DFG | -- | -- | -- |
| TYK2-P | HRD | 64 | TYK2-P | HRD |
| ULK4 | DFG, VIAK | -- | -- | -- |
| VACAMKL | HRD | 91 | CAMKVA | HRD |
| VRK3 | DFG, HRD, VIAK | 46 | VRK3 | DFG, HRD, VIAK |