TABLE II.

Final multivariable odds ratios for risk of failure to achieve EFS24 on full dataset (N = 2,525)

	IPI24
	OR	95% CI
Age
Per year over 70	1.06	1.03–1.08
Stage
I	Ref
II	1.06	0.87–1.29
III	1.16	0.96–1.40
IV	1.50	1.30–1.73
ECOG PSa
0	Ref
1	1.00	0.88–1.13
≥2	1.39	1.19–1.62
Normalized LDHb
Per unit increase if ≤1.3	2.57	1.67–4.05c
Per unit increase if >1.3	1.28	1.16–1.42c
Bulky disease
<10 cm	Ref
≥10 cm	1.28	1.02–1.60
ALC
Per unit increase 109/L	0.81	0.68–0.97
Sex
Female	Ref
Male	1.36	1.13–1.62

^aECOG PS categories for 0 and 1 were collapsed in the implementation of the final model due to identical risk

^bNormalized LDH = LDH/ULN.

^cBootstrap estimates from segmented model.