. 2016 Mar 21;11(3):e0151901. doi: 10.1371/journal.pone.0151901

Table 3. Genotype distribution and allele frequency of SIRT1 variants in control and breast cancer groups.

Data are expressed as number and percentage, n (%).

		Control(n = 439)	Breast cancer(n = 541)	OR	95% CI	p value
rs3758391
	*Genotype*
	TT	149 (33.9)	321 (59.3)	2.840	2.186–3.689	< 0.0001^***
	CC+CT	290 (66.1)	220 (40.7)	2.840	2.186–3.689	< 0.0001^***
	*Allele*
	C	384 (43.7)	256 (23.7)	2.508	2.067–3.044	< 0.0001^***
	T	494 (56.3)	826 (76.3)	2.508	2.067–3.044	< 0.0001^***
rs3740051
	*Genotype*
	AA	307 (69.9)	332 (61.4)	1.464	1.120–1.913	0.006^**
	GG+AG	132 (30.1)	209 (38.6)	1.464	1.120–1.913	0.006^**
	*Allele*
	A	733 (83.5)	843 (77.9)	1.433	1.140–1.802	0.002^**
	G	145 (16.5)	239 (22.1)	1.433	1.140–1.802	0.002^**
rs12778366
	*Genotype*
	TT	57 (13.0)	305 (56.4)	8.661	6.251–12.001	< 0.0001^***
	CC+CT	382 (87.0)	236 (43.6)	8.661	6.251–12.001	< 0.0001^***
	*Allele*
	C	538 (61.3)	263 (24.3)	4.928	4.057–5.984	< 0.0001^***
	T	340 (38.7)	819 (75.7)	4.928	4.057–5.984	< 0.0001^***

** and *** represent statistical significance at p < 0.01 and p < 0.001, respectively. OR, odds ratio; CI, confidence intervals