Table 4. Association of SIRT1 rs3758391 gene polymorphism with breast cancer clinicopathological variables.

Data are expressed as number and percentage, n (%).

Characteristics		TT	CC+CT	OR	95% CI	p value
Type
	Ductal	282 (60.1)	187 (39.9)	1.276	0.775–2.102	0.368
	Others	39 (54.2)	33 (45.8)
Histological grade†
	1	5 (14.3)	30 (85.7)	7.709	2.932–20.275	< 0.0001*** a
	2	230 (56.2)	179 (43.8)	6.085	3.153–11.743	< 0.0001*** b
	3	86 (88.7)	11 (11.3)	46.909	15.060–146.110	< 0.0001*** c
Tumor size
	T2	201 (57.9)	146 (42.1)	1.178	0.822–1.688	0.412
	T3+T4	120 (61.9)	74 (38.1)
Lymph node invasion
	N1	30 (27.8)	78 (72.2)	4.705	2.900–7.633	< 0.0001*** a
	N2	190 (64.4)	105 (35.6)	1.509	0.966–2.356	0.079 b
	N3	101 (73.2)	37 (26.8)	7.097	4.034–12.488	< 0.0001*** c
Metastasis
	Absence	245 (58.1)	177 (41.9)	1.277	0.838–1.946	0.291
	Presence	76 (63.9)	43 (36.1)
ER status
	Negative	257 (57.9)	187 (42.1)	1.411	0.890–2.236	0.171
	Positive	64 (66.0)	33 (34.0)
PR status
	Negative	262 (58.0)	190 (42.0)	1.426	0.885–2.299	0.158
	Positive	59 (66.3)	30 (33.7)

*** represents significant difference at p < 0.001.

^a 2 versus 1

^b 3 versus 2

^c 3 versus 1

† modified Bloom–Richardson grading system; T size of the tumor; N regional lymph node involvement; ER, estrogen receptor; PR, progesterone receptor