Table 6. Association of SIRT1 rs12778366 gene polymorphism with breast cancer clinicopathological variables.
Data are expressed as number and percentage, n (%).
| Characteristics | TT | CC+CT | OR | 95% CI | p value | |
|---|---|---|---|---|---|---|
| Type | ||||||
| Ductal | 265 (56.5) | 204 (43.5) | 1.039 | 0.631–1.713 | 0.899 | |
| Others | 40 (55.6) | 32 (44.4) | ||||
| Histological grade† | ||||||
| 1 | 5 (14.3) | 30 (85.7) | 8.435 | 3.207–22.190 | < 0.0001 *** a | |
| 2 | 239 (58.4) | 170 (41.6) | 1.205 | 0.764–1.903 | 0.491 b | |
| 3 | 61 (62.9) | 36 (37.1) | 10.167 | 3.620–28.556 | < 0.0001 *** c | |
| Tumor size | ||||||
| T2 | 190 (54.8) | 157 (45.2) | 0.831 | 0.582–1.187 | 0.321 | |
| T3+T4 | 115 (59.3) | 79 (40.7) | ||||
| Lymph node invasion | ||||||
| N1 | 44 (40.7) | 64 (59.3) | 2.151 | 1.373–3.370 | 0.001** a | |
| N2 | 176 (59.7) | 119 (40.3) | 1.084 | 0.716–1.641 | 0.752 b | |
| N3 | 85 (61.6) | 53 (38.4) | 2.333 | 1.394–3.904 | 0.001** c | |
| Metastasis | ||||||
| Absence | 229 (54.3) | 193 (45.7) | 0.671 | 0.441–1.022 | 0.075 | |
| Presence | 76 (63.9) | 43 (36.1) | ||||
| ER status | ||||||
| Negative | 263 (59.2) | 181 (40.8) | 1.903 | 1.220–2.967 | 0.005** | |
| Positive | 42 (43.3) | 55 (56.7) | ||||
| PR status | ||||||
| Negative | 268 (59.3) | 184 (40.7) | 2.047 | 1.290–3.248 | 0.002** | |
| Positive | 37 (41.6) | 52 (58.4) |
** and *** represent significant difference at p < 0.01 and p < 0.001, respectively.
a 2 versus 1
b 3 versus 2
c 3 versus 1
† modified Bloom–Richardson grading system; T size of the tumor; N regional lymph node involvement; ER, estrogen receptor; PR, progesterone receptor