Table 5. Immunohistochemical score of normal, DMH, DMH-DOX and DOX-treated rats.

	NF-κB (Nuclear)	MMP-9 (Cytoplasmic)	VEGF (Cytoplasmic)	p53 (Nuclear)	Cyt-c (Cytoplasmic)	Caspase-3 (Cytoplasmic)	Caspase-9 (Cytoplasmic)
Normal Control (Colon)	(1–2)+	1+	1+	3+	2+	2+	2+
DMH-10 wks (Colon)	3+	2+	2+	2+	(1–2)+	1+	(0–1)+
DMH-20 wks (Colon)	2+	2+	2+	(1–2)+	1+	(0–1)+	(0–1)+
DMH-DOX (10mg/kg) (Colon)	2+	2+	2+	1+	(0–1)+	(1–2)+	1+
DMH-DOX (20mg/kg) (Colon)	2+	2+	(2–3)+	1+	0	1+	(0–1)+
DMH-DOX (20mg/kg) (Small intestine)	3+	2+	2+	(1–2)+	1+	1+	0
Normal Control (Small intestine)	1+	0	(1–2)+	2+	2+	2+	2+
DOX (5mg/kg) (Colon)	2+	1+	2+	2+	1+	2+	1+
DOX (5mg/kg) (Small intestine)	2+	1+	2+	2+	1+	2+	1+
DOX (10mg/kg) (Colon)	2+	1+	2+	2+	(1–2)+	2+	1+
DOX (10mg/kg) (Small intestine)	3+	1+	2+	2+	1+	2+	1+
DOX (20mg/kg) (Colon)	2+	2+	2+	3+	1+	(1–2)+	(0–1)+
DOX (20mg/kg) (Small intestine)	2+	2+	(2–3)+	(2–3)+	1+	1+	1+