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. 2015 Aug 28;5(2):e1078056. doi: 10.1080/2162402X.2015.1078056

Figure 5.

Figure 5.

161-Ab reduces proliferation but increases apoptotic death. RENCA and CT26 tumor sections were prepared and analyzed for proliferation (Ki-67) and apoptosis (TUNEL). (A) Representative images of immunohistochemical staining for Ki-67 (Bar size for RENCA tumors is 100 μm and for CT26 tumor is 25 μm), and Determination of the Ki-67 positive fraction of cells (n = 4); (B) Representative images of immunohistochemical staining for apoptosis (TUNEL, bar size for RENCA tumors is 50 μm and for CT26 tumor is 25 μm), and quantification of the number of apoptotic cells per mm2 (n = 4-5); (C) Determination of the concentration of activated caspase 3 in tumor lysates by ELISA (n = 4–5).