Table 2.
T cell subset | DC | Meana | Standard Error | P |
---|---|---|---|---|
CD3+CD45RO+BTLA+ | Yes | 258.54 | 20.97 | 0.03 |
No | −24.54 | 115.63 | ||
CD3+CD4+CD45RO+BTLA+ | Yes | 75.08 | 23.14 | 0.05 |
No | −21.50 | 26.96 | ||
CD3+CD4+CXCR3+CCR5+ CCR6+IL-23R+ | Yes | 95.06 | 56.69 | 0.05 |
No | −25.76 | 17.49 | ||
CD3+BTLA+CTLA-4+ | Yes | 20.70 | 81.77 | 0.03 |
No | −27.44 | 35.13 | ||
T cell subset | OR | Meana | Standard Error | P |
CD3+ CD4+CD45RO+ICOS+ | Yes | 319.91 | 101.46 | 0.05 |
No | 96.05 | 51.78 | ||
CD3+CD4+CD45RO+BTLA+ | Yes | 81.49 | 31.51 | 0.05 |
No | 1.62 | 24.11 | ||
CD3+CD8+CD45RO+BTLA+ | Yes | 67.90 | 25.59 | 0.05 |
No | −4.92 | 22.79 | ||
CD3+CD45RO+PD-1+ | Yes | 256.87 | 101.18 | 0.05 |
No | 38.96 | 36.48 | ||
CD3+CD8+CD45RO+PD-1+ | Yes | 170.57 | 72.80 | 0.05 |
No | 21.14 | 30.78 |
DC: disease control; OR: objective response; a relative difference of the mean of the % of positive cells between baseline and W12 in PBMCs from melanoma patients; number of patients with DC = 19; number of patients without DC = 12; number of patients with = OR = 14; number of patients without OR = 17.