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Schematic representation of the novel role of IFNgamma/NOX4 induced ROS production as a barrier against tumorigenesis: similarly as in phagocytes, where activation of ROS by IFNgamma/NOX2 results in a ‘respiratory burst’ and pathogen killing, generation of ROS in tumor cells caused by IFNgamma-induced TGFbeta activation of NOX4 results in DNA damage and proliferation arrest/cellular senescence or apoptosis.
