Table 3.

Significant clusters of convergence in the ALE correlation analysis

Cluster No.	Volume mm3	MNI coordinates1			Lat.	Macroanatomical and cytoarchitectonic region	rs
		x	y	z
CAG repeat length
Cluster 1	2,576	12	11	6	R	caudate nucleus; putamen; nucleus accumbens	0.54
Age
Cluster 1	2,080	−39	−27	46	L	precentral gyrus, Ml (BA 4p, 4a); postcentral gyrus, SI (BA 3b, 3a, 2); inferior parietal cortex (PFt); intraparietal sulcus (hIP2)	0.53
Cluster 2	1,512	4	14	−4	R	caudate nucleus; putamen	0.51
Cluster 3	1,488	36	−24	46	R	precentral gyrus, M1 (BA 4p, 4a), PMC (BA 6)	0.56
Cluster 4	1,144	−52	−10	0	L	parietal operculum, SII (OP4); Heschl's gyrus, PAC (TE 1.2, 1.0)	0.49
Cluster 5	200	−10	16	0	L	caudate nucleus; putamen	0.47
Estimated disease burden
Cluster 1	3,216	8	14	−6	R	caudate nucleus; putamen; pallidum; nucleus accumbens	0.62
Cluster 2	1,416	36	−24	46	R	precentral gyrus, M1 (BA 4p, 4a), PMC (BA 6)	0.49
Cluster 3	992	−42	−34	38	L	precentral gyrus, M1 (BA 4p); postcentral gyrus, SI (BA 3b, 3a, 2); inferior parietal cortex (PFt)	0.48
Estimated disease progression
Cluster 1	1,416	36	−24	46	R	precentral gyrus, M1 (BA 4p, 4a), PMC (BA 6)	0.54
Cluster 2	1,056	−6	8	0	L	caudate nucleus	0.55
Cluster 3	600	−40	−30	40	L	precentral gyrus, M1 (BA 4p); postcentral gyrus, SI (BA 3b, 3a, 2)	0.55
UHDRS motor score
Cluster 1	2,040	−39	−27	46	L	precentral gyrus, M1 (BA 4p, 4a); postcentral gyrus, SI (BA 3b, 3a, 2); inferior parietal cortex (PFt); intraparietal sulcus (hIP2)	0.52
Cluster 2	1,496	36	−24	46	R	precentral gyrus, M1 (BA 4p, 4a), PMC (BA 6)	0.56
Cluster 3	1,072	12	4	5	R	caudate nucleus	0.51
Cluster 4	424	−52	−8	0	L	parietal operculum, SII (OP4); Heschl's gyrus, PAC (TE 1.2, 1.0)	0.47

Lat. = Laterality; L = left; R = right; r_s = Spearman's rank correlation coefficient; PAC = primary auditory cortex; BA = Brodmann area.

¹Montreal Neurological Institute (MNI) coordinates (x, y, z) for the maximum ALE value.