Table 2.
Best-Fit Solutions of Cyclophilin Microscopic Rate Constantsa
| CypA | CypB | CypC | GeoCyp | |
|---|---|---|---|---|
| kAB (×106 s−1 M−1) | 3.2 ± 0.2 | 2.1 ± 0.2 | 4.2 ± 0.8 | 5.2 ± 1.8 |
| kBA (s−1) | 550 ± 160 | 960 ± 430 | 1620 ± 820 | 720 ± 270 |
| kBC (s−1) | 1660 ± 660 | 550 ± 290 | 370 ± 170 | 2410 ± 1330 |
| kCB (s−1) | 1070 ± 230 | 320 ± 100 | 210 ± 50 | 810 ± 370 |
| kCD (s−1) | 170 ± 40 | 200 ± 70 | 260 ± 100 | 50 ± 10 |
| kDC (×106 s−1 M−1) | 10.0 ± 0.3 | 4.9 ± 0.2 | 7.9 ± 0.3 | 7.0 ± 0.1 |
| KD-cis (µM) | 17 ± 4 | 40 ± 14 | 32 ± 11 | 7 ± 1 |
| KD-trans (µM) | 170 ± 50 | 460 ± 230 | 400 ± 180 | 140 ± 30 |
| bound cis/trans | 1.6 ± 0.8 | 2.1 ± 1.5 | 2.1 ± 1.4 | 3.1 ± 1.0 |
| ωtrans-bound D6 (ppm) | 8.65 ± 0.04 | 8.63 ± 0.07 | 8.63 ± 0.06 | 8.14 ± 0.50 |
| ωcis-bound D6 (ppm) | 8.43 ± 0.03 | 9.76 ± 0.96 | 8.20 ± 1.05 | 8.93 ± 0.04 |
| ωtrans-bound L7 (ppm) | 8.30 ± 0.01 | 8.38 ± 0.05 | 8.36 ± 0.04 | 8.05 ± 0.16 |
| ωcis-bound L7 (ppm) | 8.26 ± 0.01 | 8.25 ± 0.02 | 8.23 ± 0.05 | 8.36 ± 0.07 |
a
Standard deviation determined from the 20 best fits to the data.