Table 1.
Baseline Characteristics of SHARP Participants by CVD Risk and CKD Stage at Randomization
| Overall N = 9,270 | By 5-year Risk of CVD |
By CKD Stage |
||||||
|---|---|---|---|---|---|---|---|---|
| <10% (n = 2,489) | 10%-<20% (n = 2,997) | ≥20% (n = 3,784) | 3a (n = 2,323) | 4b (n = 2,663) | 5c (n = 1,259) | On dialysis (n = 3,025) | ||
| Age, y | 62 ± 12 | 52 ± 8 | 61 ± 11 | 69 ± 10 | 63 ± 12 | 63 ± 12 | 62 ± 12 | 60 ± 12 |
| Male sex | 5,800 (63) | 1,206 (48) | 1,915 (64) | 2,679 (71) | 1,691 (73) | 1,562 (59) | 629 (50) | 1,918 (63) |
| Current smoker | 1,243 (13) | 237 (10) | 443 (15) | 563 (15) | 299 (13) | 330 (12) | 142 (11) | 472 (16) |
| Previous vascular disease | 1,393 (15) | 44 (2) | 173 (6) | 1,176 (31) | 343 (15) | 400 (15) | 189 (15) | 461 (15) |
| Diabetes mellitus | 2,091 (23) | 106 (4) | 388 (13) | 1,597 (42) | 557 (24) | 611 (23) | 255 (20) | 668 (22) |
| Body mass index, kg/m² | 27.1 ± 5.6 | 26.9 ± 5.5 | 27.1 ± 5.6 | 27.2 ± 5.7 | 27.7 ± 5.1 | 27.5 ± 5.7 | 26.5 ± 5.4 | 26.5 ± 5.9 |
| Cholesterol | ||||||||
| Total, mmol/L | 4.89 ± 1.18 | 5.05 ± 1.08 | 4.91 ± 1.14 | 4.76 ± 1.26 | 5.05 ± 1.13 | 5.09 ± 1.15 | 4.79 ± 1.24 | 4.63 ± 1.17 |
| HDL, mmol/L | 1.12 ± 0.34 | 2.89 ± 0.82 | 2.78 ± 0.86 | 2.69 ± 0.91 | 1.14 ± 0.34 | 1.14 ± 0.34 | 1.11 ± 0.33 | 1.08 ± 0.35 |
| LDL, mmol/L | 2.78 ± 0.87 | 1.13 ± 0.33 | 1.13 ± 0.35 | 1.06 ± 0.33 | 2.91 ± 0.85 | 2.92 ± 0.85 | 2.69 ± 0.9 | 2.58 ± 0.86 |
| Triglycerides, mmol/L | 2.32 ± 1.72 | 2.26 ± 1.47 | 2.34 ± 1.57 | 2.35 ± 1.97 | 2.43 ± 1.95 | 2.35 ± 1.45 | 2.09 ± 1.43 | 2.32 ± 1.85 |
| Diastolic BP, mm Hg | 79 ± 13 | 82 ± 12 | 80 ± 13 | 77 ± 13 | 80 ± 13 | 80 ± 13 | 80 ± 12 | 78 ± 13 |
| Systolic BP, mm Hg | 139 ± 22 | 132 ± 18 | 138 ± 21 | 144 ± 23 | 139 ± 20 | 139 ± 21 | 141 ± 21 | 138 ± 24 |
| 5-year risk of CVD | ||||||||
| <10% | 2,489 (27) | 995 (43) | 873 (33) | 285 (23) | 336 (11) | |||
| 10%-<20% | 2,997 (32) | 769 (33) | 915 (34) | 366 (29) | 947 (31) | |||
| ≥20% | 3,784 (41) | 559 (24) | 875 (33) | 608 (48) | 1,742 (58) | |||
Note: Values for categorical variables are given as number (percentage); for continuous variables, as mean ± standard deviation.
Abbreviations: BP, blood pressure; CKD, chronic kidney disease; CVD, cardiovascular disease; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL, low-density lipoprotein; SHARP, Study of Heart and Renal Protection.
a
eGFR ≥ 30 mL/min/1.73 m2. 83% of participants in this category with CKD stage 3b (eGFR 30-45 mL/min/1.73 m2).
b
eGFR of 15 to <30 mL/min/1.73 m2.
c
eGFR < 15 mL/min/1.73 m2; not on dialysis therapy.