Table 3.

Microcomputed tomography (μCT) derived cortical bone parameters at the distal femur and femoral diaphysis from animals fed standard rodent chow (Control), a 30% moderately high-fat (HF) diet, or a combined 30% high-fat/40% high-fructose (HF/F) diet.

	Control	HF	HF/F
Distal Femur
3D Ct.Th, mm	0.506 ± 0.005	0.551 ± 0.007***	0.550 ± 0.012**
Tt.Ar, mm2	15.34 ± 0.29	15.05 ± 0.32	15.46 ± 0.30
Ct.Ar, mm2	6.52 ± 0.07	6.87 ± 0.09	7.00 ± 0.18*
Ct.Ar/Tt.Ar, %	42.6 ± 0.7	45.8 ± 0.8*	45.3 ± 0.8
vTMD, mg/cm3	1.330 ± 0.004	1.374 ± 0.007**	1.364 ± 0.007**
Femoral Diaphysis
3D Ct.Th, mm	0.735 ± 0.004	0.768 ± 0.009**	0.772 ± 0.011**
Tt.Ar, mm2	11.83 ± 0.15	12.02 ± 0.39	12.01 ± 0.27
Ct.Ar, mm2	6.99 ± 0.07	7.33 ± 0.21	7.40 ± 0.16
Ct.Ar/Tt.Ar, %	59.6 ± 0.5	61.1 ± 0.5	61.6 ± 0.4*
vTMD, mg/cm3	1.432 ± 0.006	1.460 ± 0.009*	1.455 ± 0.006*

Data are means ± SEM from n = 7–10/group.

^*p<0.05,

^**p<0.01,

^***p<0.001 vs. Control.

3D Ct.Th = three-dimensional cortical thickness, Tt.Ar = total cross-sectional area, Ct.Ar = cortical bone area, Ma.Ar = medullary area, Ct.Ar/Tt.Ar = cortical bone area fraction, vTMD = volumetric tissue mineral density.