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F(ab) conjugation of QD605, QD655, and QD705 (for sizes and shapes cf. Table 1) was performed by transferring the amine-reactive QDs to maleimide-reactive QDs (mal-QD) using a sulfo-EMCS crosslinker (left). IgG was fragmented to F(ab) using a commercial fragmentation kit. The available disulfides on the F(ab) were reduced to sulfhydryls, which allowed a conjugation to the mal-QDs.
