Case # | Tumor # | Signalment | Gross appearance |
Amyloid in tumor |
Islet amyloidosis |
Insulin | Gastrin | Glucagon | Somatostatin | VIP | Synaptophysin | Chromogranin | Pancreatic polypeptide |
Solid | Capsule | Packeting | Very vascular |
Mitotic rate |
Acinar pattern |
Thick stroma Focal (F) or Diffuse (D) |
Granularity | Size on slide |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 23 yr F | 3 cm diameter |
no | no | mild multifocal |
negative | mild multifocal |
positive | negative | positive | positive | negative | − | − | ++ | + | 1 per 10 fields |
+ | F | − | 1.5 × 1cm |
2 | NS | no | no | mild multifocal |
negative | negative | mild multifocal |
negative | positive | positive | mild multifocal |
+ | + | ++ | − | 0 per 10 fields |
− | D | − | 5mm | ||
2 | 3 | 28 yr F | NS | no | no | mild multifocal |
negative | negative | negative | negative | positive | positive | negative | + | + | + | − | 1 per 10 fields |
− | F | − | 5mm |
4 | NS | no | no | mild multifocal |
negative | mild multifocal |
mild multifocal |
negative | positive | positive | negative | + | − | ++ | − | 0 | − | − | + | 2mm | ||
5 | NS | no | no | mild multifocal |
negative | mild multifocal |
mild multifocal |
negative | positive | positive | negative | + | + | ++ | − | 0 | − | − | − | 1mm | ||
6 | NS | no | no | mild multifocal |
negative | mild multifocal |
mild multifocal |
negative | positive | positive | negative | + | − | ++ | − | 0 | − | − | − | 1 × 0.5mm |
||
3 | 7 | 23 yr F | NS | no | no | mild multifocal |
negative | negative | mild multifocal |
negative | positive | positive | mild multifocal |
+ | + | + | − | 1 per 10 fields |
− | F | − | 7 × 5mm |
4 | 8 | 26 yr F | NS | no | yes | mild multifocal |
negative | mild multifocal |
mild multifocal |
negative | positive | positive | negative | + | − | + | − | 0 | − | − | + | 2 × 1mm |
9 | NS | no | yes | mild multifocal |
negative | negative | negative | negative | positive | positive | negative | + | + | ++ | − | 0 | − | − | − | 1.5 × 1mm |
||
5 | 10 | 24 yr F | NS | no | no | negative | negative | negative | negative | negative | positive | positive | negative | + | + | ++ | − | 0 | − | − | − | 2 × 1mm |
6 | 11 | 17 yr F | NS | no | no | positive | negative | ND | ND | ND | ND | ND | ND | + | − | ++ | − | 0 | − | − | − | 0.5mm |
7 | 12 | 26 yr F | NS | yes | yes | mild multifocal |
negative | negative | negative | negative | positive | positive | negative | + | − | ++ | − | 1 per 10 fields |
− | − | + | 2mm |
8 | 13 | 20 yr F | NS | no | no | mild multifocal |
negative | negative | negative | negative | positive | positive | negative | + | − | + | − | 0 | − | − | − | 1mm |
9 | 14 | 12 yr F | NS | no | yes | negative | negative | negative | negative | negative | positive | positive | negative | + | + | ++ | − | 0 | − | − | + | 1 × 0.5mm |
10 | 15 | 19 yr F | NS | no | yes | negative | negative | negative | negative | negative | positive | positive | negative | + | − | + | − | 0 | − | − | − | 1 × 0.5mm |
11 | 16 | 24 yr F | NS | no | yes | positive | negative | negative | negative | negative | positive | positive | negative | + | − | + | − | 0 | − | − | − | 0.75mm |
12 | 17 | 26 yr F | NS | yes | yes | negative | negative | negative | negative | negative | positive | ND | negative | + | − | ++ | − | 0 | − | − | − | 1mm |
18 | NS | no | yes | positive | negative | negative | negative | ND | ND | ND | ND | + | − | + | − | 0 | − | − | + | 0.5mm | ||
19 | NS | yes | yes | positive | negative | mild multifocal |
mild multifocal |
negative | ND | ND | ND | + | − | + | − | 0 | − | − | + | 1 × 0.5mm |
||
20 | NS | no | yes | mild multifocal |
negative | negative | mild multifocal |
negative | positive | ND | negative | + | − | ++ | − | 1 | − | − | − | 1mm | ||
21 | NS | no | yes | negative | negative | negative | negative | negative | ND | ND | ND | + | − | + | − | 0 | − | − | − | 1 × 0.5mm |
||
NS = Not seen |
ND = Not done |
ND = Not done |
ND = Not done |
ND = Not done |
ND = Not done |
ND = Not done |