Table 2.

Relationship of early dyspnea relief to EQ-5D measures at discharge and day 30.

	Univariable			Baseline EQ-5D Adjusted			Multivariable
EQ-5D Measure	Estimate	95% CI	P-Value	Estimate	95% CI	P-Value	Estimate	95% CI	P-Value
Discharge
US Utility Scorea	0.051	0.041 to 0.061	<0.0001	0.03	0.021 to 0.039	<0.0001	0.029	0.020 to 0.038	<0.0001
VASb	8.1	7.0 to 9.2	<0.0001	5.6	4.6 to 6.6	<0.0001	5.1	4.1 to 6.0	<0.0001
Day 30
US Utility Scorec	0.032	0.022 to 0.042	<0.0001	0.018	0.008 to 0.028	0.0005	0.016	0.006 to 0.025	0.0012
VASd	6.3	5.1 to 7.4	<0.0001	4.6	3.5 to 5.6	<0.0001	3.9	2.8 to 4.9	<0.0001

^aMultivariable model is adjusted for baseline utility score, age, gender, race, BMI, cerebrovascular disease, chronic renal disease, heart rate, peripheral vascular disease, hyperlipidemia, prior hospitalization in past year, log of BUN, NYHA classification, smoking, sodium, log of creatinine, and diabetes.

^bMultivariable model is adjusted for baseline vas, age, race, ACEI or ARB use, chronic renal disease, history of ICD/CRT, baseline diastolic blood pressure, peripheral vascular disease, respiratory rate, log of BUN, NYHA classification, pre-randomization oral anticoagulant use, jvp, smoking and BMI.

^cMultivariable model is adjusted for baseline utility score, age, gender, race, BMI, cerebrovascular disease, chronic renal disease, hemoglobin, heart rate, prior mi, sodium, peripheral vascular disease, respiratory rate, prior hospitalization in past year, log of BUN, NYHA classification, pre-randomization digoxin use, baseline weight.

^dMultivariable model is adjusted for baseline vas, age, race, chronic renal disease, baseline diastolic blood pressure, hemoglobin, prior mi, peripheral vascular disease, respiratory rate, prior hospitalization in past year, log of BUN, pre-randomization oral anticoagulant use, and jvp.