Table 1.

Development of clinical symptoms in animals intratra-cheally inoculated with PBS (control), P. gingivalis W83 (WT), P. gingivalis gingipain mutants (ΔRgp, ΔKgp, or KRAB), or inhibi-tor-pretreated P. gingivalis W83 (W83-KYT)

	Respiratory	Weight	Loss of	Activity	Ruffled	Ataxia
	Failure	loss	appetite	loss	fur
PBS	0/16	0/16	0/16	0/16	0/16	0/16
WT-W83	16/16	12/16	12/16	16/16	16/16	14/16
ΔKgp	12/16	6/16	10/16	12/16	12/16	10/16
ΔRgp	8/16	6/16	10/16	8/16	10/16	8/16
KRAB	2/16	6/16	0/16	2/16	0/16	0/16
W83-KYT	2/16	6/16	0/16	2/16	0/16	0/16

Values are presented as numbers of animals showing a specific symptom per group.