Table 2.
Edema, necrosis, and hemorrhage in 40-week-old animals intratracheally inoculated with 50 µl of PBS (PBS), P. gingivalis W83 (WT), gingipain mutants (ΔKgp, ΔRgp, or KRAB), or a suspension of P. gingivalis W83 pretreated with inhibitors (W83-KYT)
| Edema | Necrosis | Hemorrhage | |
|---|---|---|---|
| PBS | 0/8 | 0/8 | 0/8 |
| WT-W83 | 7/8 | 4/8 | 8/8 |
| ΔKgp | 6/8 | 4/8 | 5/8 |
| ΔRgp | 3/8 | 2/8 | 4/8 |
| KRAB | 0/8 | 0/8 | 1/8 |
| W83-KYT | 0/8 | 0/8 | 1/8 |
Data were corroborated by histopathological changes in the lungs of infected animals. Values are presented as numbers of animals per group.