Table 3. Univariable Cox models for Overall Survival and Disease-Free Survival Analyses.
Overall Survival | Disease-Free Survival | |||||
---|---|---|---|---|---|---|
HR | 95% CI | P | HR | 95% CI | P | |
Post-induction PET (N2-avid v N2-negative) | 1.50 | 0.75, 3.00 | 0.3 | 1.05 | 0.59, 1.86 | 0.9 |
Pathological N2 Status (N2-persistent v N2-negative) | 0.98 | 0.54, 1.77 | 0.9 | 1.58 | 0.94, 2.63 | 0.082 |
Pathologic Staging (≥ypIIIA v <ypIIIA) | 1.09 | 0.59, 1.99 | 0.8 | 1.67 | 0.99, 2.82 | 0.056 |
Age at Surgery | 0.99 | 0.96, 1.03 | 0.6 | 0.97 | 0.94, 1.00 | 0.044 |
Male | 1.49 | 0.82, 2.70 | 0.2 | 1.07 | 0.66, 1.75 | 0.8 |
Smoking, yes | 1.02 | 0.48, 2.20 | 0.9 | 0.93 | 0.48, 1.78 | 0.8 |
Smoking Pack-years >30, yes | 0.98 | 0.54, 1.75 | 0.9 | 0.71 | 0.43, 1.16 | 0.2 |
Pulmonary comorbidity, yes | 1.07 | 0.55, 2.10 | 0.8 | 0.77 | 0.44, 1.35 | 0.4 |
Cardiac comorbidity, yes | 0.95 | 0.48, 1.88 | 0.9 | 0.69 | 0.40, 1.21 | 0.2 |
NIDDM, yes | 1.43 | 0.50, 4.09 | 0.5 | 1.73 | 0.68, 4.41 | 0.3 |
FEV1 (%) | 0.99 | 0.97, 1.01 | 0.2 | 0.99 | 0.97, 1.00 | 0.10 |
Diffusion (%) | 1.00 | 0.99, 1.02 | 0.6 | 1.01 | 1.00, 1.02 | 0.2 |
Adenocarcinoma, yes | 1.07 | 0.52, 2.23 | 0.9 | 1.65 | 0.88, 3.10 | 0.12 |
EGFR, present | 0.74 | 0.26, 2.12 | 0.6 | 0.79 | 0.35, 1.75 | 0.6 |
KRAS, present | 1.66 | 0.81, 3.40 | 0.2 | 1.18 | 0.64, 2.20 | 0.6 |
Adjuvant Therapy | ||||||
PORT-only only vs None | 1.19 | 0.61, 2.33 | 0.6 | 1.14 | 0.65, 2.01 | 0.6 |
Adjuvant Ch-only vs None | 0.64 | 0.26, 1.58 | 0.3 | 0.78 | 0.37, 1.63 | 0.5 |
PORT+Adjuvant Ch vs None | 0.60 | 0.17, 2.08 | 0.4 | 0.94 | 0.38, 2.31 | 0.9 |
Resection: R1 vs R0 | 2.08 | 0.87, 4.97 | 0.10 | 1.46 | 0.66, 3.22 | 0.3 |
Resection: R2 vs R0 | 1.33 | 0.41, 4.34 | 0.6 | 2.32 | 0.92, 5.88 | 0.075 |
Pathologic T-Stage (≥IIA v <IIA)a | 1.80 | 0.98, 3.31 | 0.058 | 2.22 | 1.33, 3.73 | 0.002 |
Pathologic T-stage: 45 had <IIA (0, IA, IB) and 55 had ≥IIA (includes IIA, IIB, IIIA, III and IV). NIDDM = non-insulin dependent diabetes; PORT = post-operative radiation therapy; Ch = chemotherapy
PET = positron emission scan; NIDDM = non-insulin dependent diabetes; FEV1 = Forced expiratory volume in one second; EGFR = Endothelial growth factor receptor; KRAS = Kirsten rat sarcoma viral oncogene homolog; PORT = post-operative radiation therapy.