Table 1.
Baseline characteristics of the CHD cases, stratified by presence or absence of potentially pathogenic CNV.
| No CNV (n=371) | CNV (n=51) | Combined (n=422) | P-Value | |
|---|---|---|---|---|
| Sex, male (%) | 208 (56%) | 37 (73%) | 245 (58%) | P = 0.040a |
| Ethnicity | P = 0.49a | |||
| Caucasian | 240 (65%) | 33 (65%) | 273 (65%) | |
| African | 85 (23%) | 14 (27%) | 99 (23%) | |
| Hispanic | 18 (5%) | 1 (2%) | 19 (5%) | |
| Asian | 12 (3%) | 0 (0%) | 12 (3%) | |
| Native American | 7 (2%) | 2 (4%) | 9 (2%) | |
| Other | 9 (2%) | 1 (2%) | 10 (2%) | |
| Gestational age, weeks | 38.5 ± 2.0 | 38.0 ± 2.1 | 38.5 ± 2.1 | P = 0.062b |
| Birth weight, kg | 3.16 ± 0.60 | 3.03 ± 0.72 | 3.15 ± 0.62 | P = 0.13b |
| Diagnostic class (%) | P = 0.88a | |||
| Class 1 | 179 (48%) | 25 (49%) | 204 (48%) | |
| Class 2 | 36 (10%) | 5 (10%) | 41 (10%) | |
| Class 3 | 39 (11%) | 7 (14%) | 46 (11%) | |
| Class 4 | 117 (32%) | 14 (27%) | 131 (31%) | |
| Preoperative LOS, days | 2.2 ± 2.6 | 2.1 ± 2.7 | 2.1 ± 2.6 | P = 0.57b |
| Intubation (%) | 104 (28%) | 15 (29%) | 119 (28%) | P = 0.97a |
| Total surgical support time, min | 30 ± 50 | 20 ± 35 | 29 ± 48 | P = 0.22b |
| Delayed sternal closure (%) | 56 (15%) | 5 (10%) | 61 (14%) | P = 0.48a |
| ECMO use (%) | 22 (6%) | 1 (2%) | 23 (5%) | P = 0.40a |
| Postoperative LOS, days | 16 ± 23 | 18 ± 29 | 16 ± 24 | P = 0.62b |
| Mortality (%) | 34 (9%) | 13 (25%) | 47 (11%) | - |
Abbreviations used: CHD = congenital heart defect; CNV = potentially pathogenic copy number variant; ECMO = extracorporeal membrane oxygenation; HLHS = hypoplastic left heart syndrome; LOS = length of stay; TGA = transposition of the great arteries; VSD = ventricular septal defect.
Tests used:
a
Chi-square test
b
Wilcoxon rank sum test
Mean ± Standard Deviation are presented for continuous variables